Digital Cell Reprogramming
- UltraRepro®
- Induced Pluripotent Stem Cell
- Direct Reprogramming
UltraRepro®, equipment for digital cell reprogramming Induction
Development of stable and uniform cell reprogramming treatments through automated Entr® induction
UltraRepro
Process of Digital Cell
Reprogramming
- 1. Ultrasonic application to cell
differentiation induction medium
(environment) - 2. Wash
- 3. Ultrasonic application to HDF
Stem cell marker expression and Reprosome
induction after influx of environment
Cell reprogramming induction
Video of stem cell marker Oct4 (green) expression after influx of intracellular environment (red)
Reprosome induction
Induction of induced pluripotent stem cells (x/Entr® cells) using the Entr® automation system
Induction of induced pluripotent stem cells (x/Entr cells) after Entr application using the embryonic stem cell induction medium to human dermal fibroblasts
Verification data for induction of induced pluripotent stem cells (x/Entr® cells) using the Entr® system
Video of expression of the induced pluripotent stem cell marker Oct4 (green) after Entr application to human dermal fibroblasts
Similarities between x/Entr cells and embryonic stem cells (ES)
Verification of in vivo pluripotency of x/Entr cells
(brain cells, muscle cells, liver cells)
Succeeded in inducing mass production of the induced pluripotent stem cells
capable of pluripotency into three germ layers without teratoma formation within 6 days after Entr application.
Induction of direct reprogramming using the Entr® system
Induction of direct reprogramming after Entr application using various cell induction media to human dermal fibroblasts
Induce direct cross-differentiation using various environments.
-
Medium for cardiomyocyte
differentiation induction -
Medium for vascular endothelial
cell differentiation induction -
Medium for hepatocyte
differentiation induction -
Medium for brown adipocyte
differentiation induction
Digital Direct
Reprogramming
Cardiomyoctes (c/Entr cells)
Endothelial like cells (e/Entr cells)
Hepatocytes (h/Entr cells)
Brown adipose cells (ba/Entr cells)
