Entr® Original technology
Ultrasound-directed permeation of Environmental transition-guided cellular reprogramming
Induction of cell reprogramming and Reprosome® suitable for environmental
characteristics by introducing external environmental substances into cells using ultrasound
Entr® Principle
STEP 01
Perforation of cell membrane by ultrasound
Cell SEM imaging after ultrasound application
STEP 02
Influx of Environment
Video of influx of environment
(red, cell differentiation induction medium)
into cells after ultrasound application
STEP 03
Chromatin remodeling
Video of H2B-GFP
(green, heterochromatin-related protein)
reduction after Entr application
STEP 04
Cell reprogramming & Reprosome induction
Video of cell reprogramming induction after Entr application
Video of Reprosome induction after Entr application
Entr® System Excellence
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| Division | Conventional Cell Reprogramming Method | Entr System-Based Reprogramming | |
|---|---|---|---|
| Method | use of genetic or small molecule compounds | Use of ultrasound and cell culture medium | |
| Efficiency | Time | several months | 1 ~ 2 weeks |
| Efficiency | less than 1% | 60-80% induced | |
| Reproducibility | Manual production: Difficult and low | Automatic induction: Simple and high | |
| Safety |
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